• Not all metals are susceptible of being accumulated

  2021-10-20

  

  Not all metals are susceptible of being accumulated by insects. Tissue concentrations of essential metals like Cu and Zn are regulated in many insects and hence cannot be used to biomonitor metal pollution (Hare, 1992). A similar behaviour could explain the observed stability of Zn and Cu relative t

• Cells undergoing EMT display a downregulation of E cadherin

  2021-10-20

  

  Cells undergoing EMT display a downregulation of E-cadherin and dissociation of their junctional complexes that associates cell-cell contacts with the Calpeptin cytoskeleton, known as the adherens junction (Berx and van Roy, 2009, Birchmeier and Behrens, 1994). Adherens junctions are specialized cel

• Continuing studies of endocannabinoid ligands at GPR reveal

  2021-10-20

  

  Continuing studies of endocannabinoid ligands at GPR55 reveal that virodhamine (O-arachidonylethanolamine) and AEA can act as a partial agonists at GPR55; at high micromolar concentrations can inhibit β-arrestin recruitment (Sharir et al., 2012). It is likely that there are allosteric as well as ort

• teniposide br Materials and methods br Results br Discussion

  2021-10-20

  

  Materials and methods Results Discussion In this study, the supF forward mutation assay showed that 5OHU induced mutations in human cells and that a C→T mutation was the predominant mutation among 5OHU-induced mutations. In addition, the DNA cleavage activity assay revealed that 5OHU was ex

• br Conflicts of interest br Funding This work was supported

  2021-10-20

  

  Conflicts of interest Funding This work was supported by the National Natural Science Foundation of China (No.81670558; 81800542), and the Science & Technology Development Fund of Tianjin Education Commission for Higher Education (No.2017KJ221). Acknowledgements Introduction Free fatty

• The Notch cleavage efficiency of Aph aS containing complexes

  2021-10-19

  

  The Notch-cleavage efficiency of Aph1aS containing complexes was lower than that of Aph1aL γ-secretases, especially in combination with PS2, suggesting that Aph1aS is a determinant of low Notch-cleavage specificity, considering that the different subcellular localization of PS1 and PS2 didn't affect

• To ensure the induction of CYP enzymes by

  2021-10-19

  

  To ensure the induction of CYP enzymes by several inducers, specific monooxygenase activities of variously induced, uninduced and pooled liver microsomes were compared (Fig. 3). Although 3-MC, phenobarbital, acetone, and dexamethasone could induce CYP1A-, CYP2B-, CYP2E1-, and CYP3A-selective enzyme

• Also a large number of small molecules

  2021-10-19

  

  Also a large number of small molecules are potent G-quadruplex ligands that exhibit anti-proliferative activity in cells [39,48]. Several small molecules, for example cyclic naphthalene diimide derivative [43], cationic porphyrins [2,[49], [50], [51], [52]] and pentaheteroaryls [53], quinacridines [

• The C terminal regions in both FGF and FGF define

  2021-10-19

  

  The C-terminal regions in both FGF19 and FGF21 define their KLB interaction [15], [16], [23], [25]. However, less than 40% identity in comparative alignment of C-terminal sequences for these two proteins (Table 1) suggests that their interaction with KLB may require higher-order association with oth

• Epigenetic inheritance is regarded as the genetic

  2021-10-19

  

  Epigenetic inheritance is regarded as the genetic modification of CB-5083 that affects gene expression and related processes of other DNAs but does not directly change the DNA coding sequence [18]. Epigenetic inheritance includes DNA methylation, histone modification, and noncoding RNA expression,

• Histamine functions as a key neurotransmitter in multiple ci

  2021-10-19

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, histamine is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pathway

• Furthermore the absolute lack of E allele expression

  2021-10-19

  

  Furthermore, the absolute lack of E2 allele expression in both chronic and SVR cases, supports the protective role of the E2 allele against HCV infection at a time of exposure. However this hypothesis could not be entirely proved by this study due to lack of healthy individuals participation. Simila

• Our findings demonstrated that the expression level of full

  2021-10-19

  

  Our findings demonstrated that the expression level of full-length α1 sGC protein was higher in the malignant and benign breast tumors than that of normal tissues. Similarly, an increase in the expression of α1 sGC subunit has been detected in glioma cell lines [34]. Higher expressions of sGCα1 and

• br Materials and methods br Results

  2021-10-19

  

  Materials and methods Results Discussion Directly modulating specific target proteins and signaling pathways with small-molecule drugs or agonistic Stattic is widely used for cancer metastasis therapies [[39], [40], [41]]. ANXA7 acts as a metastasis suppressor in prostate cancer. However,

• GDC-0449 sale br Introduction br Mitochondrial dysfunction

  2021-10-19

  

  Introduction Mitochondrial dysfunction and cancer Lactate and succinate as oncometabolites Intracellular actions of lactate and succinate as tumor promoters Cell-surface receptors for lactate and succinate and their role in cancer GPR109A as the receptor for butyrate and β-hydroxybu

15903 records 547/1061 page Previous Next First page 上5页 546547548549550 下5页 Last page