• br Specificity of CD T cells and

  2022-06-17

  

  Specificity of CD4 T cells and their role in flavivirus neutralizing antibody responses CD4 T cells recognize peptides that are proteolytically processed from protein antigens and presented by MHC class II molecules on the surface of specialized antigen-presenting cells, such as dendritic cells o

• Indeed in women with different causes of epithelial

  2022-06-17

  

  Indeed, in women with different causes of epithelial layer damage, HIV infection rates have been reported to be very high [2], [3]. As observed from in vivo studies, disruption of the epithelium due to pathogens [45], [46] or chemical irritants [47], has resulted in women being at a higher risk of H

• During the structural transition the FD the PHD and

  2022-06-17

  

  During the structural transition, the FD, the PHD and the TrD retain their tertiary structure. Nevertheless, they undergo large rearrangements in their relative orientation due to secondary changes in hinge segments (R1 to R5) which refold during the low-pH induced conformational change. Particularl

• GlyRs are members of the superfamily of Cys

  2022-06-17

  

  GlyRs are members of the superfamily of Cys-loop receptors (CLRs) [3]. They form postsynaptic pentameric receptor complexes of α1 and β subunits anchored via the scaffolding protein gephyrin [4]. GlyRs are composed of several domains with the large N-terminal extracellular domain (ECD) important for

• In this study we examined whether zebrafish ionocytes

  2022-06-17

  

  In this study, we examined whether zebrafish ionocytes might also share other types of similarity in transport function with kidney cells. In addition to ion transport, mammalian kidney AbK also play key roles in xenobiotic elimination, through the action of ATP-Binding Cassette (ABC) transporters

• Work in the Ruiz i Altaba lab was

  2022-06-17

  

  Work in the Ruiz i Altaba lab was funded by grants from the Swiss National Science Foundation, the Ligue Suisse Contre le Cancer, the European FP7 Marie-Curie Initial Training Network HEALING, a James McDonnell Foundation 21st Century Science Initiative in Brain Cancer-Research Award and funds from

• Some of the key aspects of the myofibroblasts biology includ

  2022-06-17

  

  Some of the key aspects of the myofibroblasts’ biology, including their signaling sensitivity and residual regenerative potential, are shaped by their origin. In this respect, lineage studies on myofibroblast precursors are critical for increasing our understanding of the natural history of fibrosis

• The effects of FFAR and FFAR activation in different

  2022-06-17

  

  The effects of FFAR1 and FFAR2 activation in different tissues have been reported in several species (Hara et al., 2014). Herein, we report the first evidence for differential expression of FFAR1 and FFAR2 during the peripartal period in the liver of dairy cows that differ in liver metabolism, based

• The Ala to Leu substitution would reduce the

  2022-06-17

  

  The Ala116 to Leu110 substitution would reduce the size of the active-site cavity disfavoring the production of longer allylic compounds as a result of steric hindrance, according to the observations of Poulter and co-workers [29], [30]. However, this explanation appears to be unlikely since several

• br FAAH mediation of fear and extinction In addition

  2022-06-17

  

  FAAH mediation of fear and extinction In addition to being a major target and modulator of stress, the BLA is a critical node within the neural circuitry subserving learned fear behaviors. The BLA is activated during the formation, expression, and extinction of conditioned fear memories, and dama

• There might be a hedgehog dilemma in a broad class

  2022-06-16

  

  There might be a hedgehog dilemma in a broad class of games, but this paper focuses on the case where players only care about : the distance between their attitudes. Here we generalize the main example of a quadratic loss function. So, player ’s payoff is higher when the distance is closer to ’s

• The study by Pigna and collaborators provides an elegant

  2022-06-16

  

  The study by Pigna and collaborators provides an elegant demonstration why class IIa HDAC inhibition may not be suitable to protect the neuromuscular function in ALS, consistent with a recent study that showed only a transient protection of motor performance after treatment of the same ALS model wit

• br Competing interests br Funding br

  2022-06-16

  

  Competing interests Funding Ethical approval Acknowledgement Introduction Hepatitis C is a disease that infects the liver through transmission of the hepatitis C virus (HCV). Because the symptoms of this infection are not pronounced, the infected individuals may not even be aware of t

• The identity of organelles is defined by a

  2022-06-16

  

  The identity of organelles is defined by a particular set of molecules present on their surface. Most organelles in the endomembrane system (i.e., endoplasmic reticulum, Golgi apparatus, endosomes, and lysosomes) carry Rab GTPases (hereafter referred to as Rabs), which serve as binding platforms for

• GSTP c C T SNP was

  2022-06-16

  

  GSTP1 c.341C > T SNP was genotyped in 90 patients tumor and 180 normal healthy individuals. The profile of GSTP1 c.341C > T mao inhibitors and genotypes is shown in Table 2. The profile of the genotypes was in agreement with Hardy-Weinberg equilibrium (χ2 = 2.11). Minor allele frequency (341T) amon

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