• br AR signals and chemosensitivity

  2024-12-27

  

  AR signals and chemosensitivity in urothelial cancer A significant amount of patients with urothelial cancer fail to respond to cisplatin-based systemic chemotherapy, although it remains the mainstay of successful management of advanced disease. However, underlying mechanisms for chemoresistance

• br Materials and methods br Results

  2024-12-27

  

  Materials and methods Results Discussion Endophilin A1 is a membrane-binding protein that is mainly distributed in the central nervous system (Giachino et al., 1997), localizes in the dendritic shafts and spines of mature neurons (Yang et al., 2015), and relates to the function and morpholo

• Cell surface metalloproteases coordinate signaling during de

  2024-12-27

  

  Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. A disintegrin and metalloprotease 17 (ADAM17) is a well-characterized member among ADAM family, which mediates the cleavage of various cell surface proteins (Black, 2002, Black et al., 1997, Dello

• br Discussion Herein we demonstrate

  2024-12-27

  

  Discussion Herein, we demonstrate that mice deficient in L-12/15 LO are more sensitive to 3-NP-induced toxicity although a substantial individual variability in striatal lesion size in response to 3-NP in both genotypes was observed. This variability is not atypical; several studies demonstrate

• br Materials and methods br Results

  2024-12-27

  

  Materials and methods Results Discussion Conclusions These studies provide important mechanistic insights to explain the long-established physiological observation that obese adipose tissue has higher rates of basal lipolysis. Increased lipolysis contributes to increased hepatic EPO mRNA

• HT modulates cortical and hippocampal pyramidal cell functio

  2024-12-26

  

  5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal what is sodium bicarbonate as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (

• Further investigations were concerned to study the

  2024-12-26

  

  Further investigations were concerned to study the mechanisms by which GABA modulates adenosine-mediated effects in hippocampal tissue. From these results it can be concluded that endogenous GABA exerts an inhibitory effect through GABAA receptors via a predominant adenosine-mediated action and this

• Many metalloenzyme inhibitors consist of two chemical

  2024-12-26

  

  Many metalloenzyme inhibitors consist of two chemical components: the MBG, the portion of the inhibitor designed to bind to the metal, and the scaffold, the portion of the inhibitor recognized by the amino gw3965 residues that form the substrate-binding site of the metalloenzyme. The MGB is often a

• br Contemporary understanding for alcoholic cardiomyopathy U

  2024-12-26

  

  Contemporary understanding for alcoholic cardiomyopathy Up-to-date, a number of theories are postulated for alcoholic cardiomyopathy including generation of mitochondrial reactive oxygen species (ROS), oxidative stress, neurohormonal overactivation (catecholamines and angiotensin II), apoptosis a

• NOXA a member of the

  2024-12-26

  

  NOXA, a member of the pro-apoptotic B-cell lymphoma 2 (BCL-2) family, plays a vital role in regulating mitochondrial or inherent apoptotic pathways [7,8]. NOXA binds to MCL-1 with high affinity and interacts with A1 (known as BCL2A1), resulting in BIM release to trigger subsequent apoptosis [9]. In

• br Results and discussion br Conclusion In summary a

  2024-12-26

  

  Results and discussion Conclusion In summary, a series of indazole-based derivatives were synthesized and SAR studies conducted, with view to the development of a novel Aurora kinases inhibitor. The carboxylic Phenazine methosulfate NADH group extending from the C-3 position of the aniline and

• For the TSH receptor signaling at the Golgi trans Golgi

  2024-12-26

  

  For the TSH receptor, signaling at the Golgi/trans-Golgi network appears required for both rapid effects of TSH − such as Chromosome banding depolymerization, which is implicated in thyroglobulin reuptake and, thus, thyroid hormone release − and late ones, such as those on gene transcription. Contin

• br Acknowledgements M M M is the William Dow Lovett

  2024-12-26

  

  Acknowledgements M.M.M. is the William Dow Lovett Professor of Neurology and is supported by grants from the Michael J. Fox Foundation for Parkinson's Research, the American Parkinson Disease Association, the New Jersey Health Foundation/Nicholson Foundation, and by the National Institutes of Hea

• ARG I is one of the most important mammalian enzymes

  2024-12-26

  

  ARG I is one of the most important mammalian enzymes responsible for nitrogen metabolism since it comprises the main route for the elimination of excess nitrogen resulting from amino β-Pompilidotoxin receptor and nucleotide metabolism [18]. ARG I deficiency leads to hyperargininemia, characterized b

• To investigate if WP increased CAT activity

  2024-12-26

  

  To investigate if WP increased CAT activity in cells, C2C12 muscle Synthesis were treated with 0.1 to 0.4 mg/mL of WP (80.05% protein) for 24 h and then stressed with 0.75 mM H2O2 for 1 h (Xu et al., 2011). The CAT activity was significantly enhanced from 15.1 ± 0.7 to 23.7 ± 1.3 U/mg of total cell

15548 records 13/1037 page Previous Next First page 上5页 1112131415 下5页 Last page