• The environment in the postnatal

  2018-10-22

  

  The environment in the postnatal cerebral cortical may not be permissive for all lineage-reprogrammed astroglial A 779 manufacturer to differentiate into iNs. In fact, after transplantation in the neurogenic subventricular zone, we observed that both cerebellar and cortical astroglia nucleofected w

• The low percentage of overlap between

  2018-10-22

  

  The low percentage (10%) of overlap between RNA-Seq and ChIP-Seq datasets suggests an alternative role of THAP1 in regulating gene expression other than direct binding at DNA, as exists with other zinc-finger factors (Aguilo et al., 2015). This conclusion may also be supported by the relatively low

• In a search for epigenetic factors regulating chromatin

  2018-10-22

  

  In a search for epigenetic factors regulating chromatin remodeling and MaSC maintenance, we found BPTF, which is known to regulate the accessibility of DNA and stabilize the recruitment of the NURF complex to promoter regions (Li et al., 2006; Ruthenburg et al., 2011). BPTF is essential for mouse em

• Previous studies have demonstrated that the signal transduct

  2018-10-20

  

  Previous studies have demonstrated that the signal transduction pathways mediating ATF3 expression include c-Jun co-expressed with ATF3 in the nervous system after injury and stress (Hunt et al., 2012). The selective JNK/c-Jun inhibitor SP600125 fully blocks ATF3 induction in adult rat ganglion neur

• The cell cycle arrest seen postnatally might be explained

  2018-10-20

  

  The S63845 arrest seen postnatally might be explained by an increase in oxygenation compared with the fetal state (Puente et al., 2014). Puente et al. showed that the level of reactive oxygen species (ROS) increases postnatally along with oxidative DNA damage and the DNA damage response (DDR), where

• One most recent study first reported the feasibility of usin

  2018-10-20

  

  One most recent study first reported the feasibility of using undifferentiated hPSC molarity and dilution for cardiac differentiation in suspension by small molecules modulating Wnt pathway (Kempf et al., 2014). With a fixed differentiation condition without controlling cell aggregate size, the aut

• Mammalian muscle differentiation is governed by the expressi

  2018-10-20

  

  Mammalian muscle differentiation is governed by the expression of a series of master regulatory transcription factors, collectively called myogenic regulatory factors (MRFs) (Bentzinger et al., 2012; Molkentin and Olson, 1996). Proliferating myoblasts start expressing MRFs, i.e. MyoD, myogenin, MRF4

• Microarray based global hierarchical clustering clearly

  2018-10-20

  

  Microarray-based global hierarchical clustering clearly separated all the directly isolated keratinocyte populations. In the first round of analysis () where we focused on known and well characterized populations the Plet population clearly separated from the rest of the populations, which is probab

• Several studies have reported the existence of rare CD

  2018-10-20

  

  Several studies have reported the existence of rare CD34− HSCs upstream of the major population of CD34+ HSCs in the human hematopoietic hierarchy (Anjos-Afonso et al., 2013; Bhatia et al., 1998). Interestingly, the first HSCs found in the human embryo are CD34+ and give rise exclusively to a CD34+C

• br Results br Discussion Here we

  2018-10-20

  

  Results Discussion Here, we demonstrate that the status of the X chromosome is dynamic during human female somatic cell reprogramming. Extending previous studies that examined X chromosome status in iPSCs after completion of reprogramming, we determined the change of X chromosome status in vol

• Retinal degenerative diseases such as inherited or age relat

  2018-10-20

  

  Retinal degenerative diseases such as inherited or age-related eye diseases resulting in the loss of photoreceptors are the leading cause of blindness in Europe. To date, around 4% of the western world population suffers from one of these diseases, and unfortunately, no cures exist to treat the majo

• Introduction Reprogramming somatic cells to induced pluripot

  2018-10-20

  

  Introduction Reprogramming somatic stavudine manufacturer to induced pluripotent stem cells (iPSCs) holds great promise for disease modeling and therapeutic applications. Among the challenges that remain is the extended time frame and variable efficiency of transcription factor-based reprogramming

• To test whether the direction of the

  2018-10-20

  

  To test whether the direction of the genomic strand targeted by the gRNA molecule was a factor in its capacity to recruit dCas9 and activate expression of the endogenous locus, we designed a gRNA molecule (gRNA4) targeting the minus strand of the same region for which gRNA3 was designed (PAM separat

• A recent study indicated that

  2018-10-20

  

  A recent study indicated that XIST expression can be lost upon prolonged passaging of female hiPSCs, referred to as “erosion of XCI” (Mekhoubad et al., 2012). This epigenetic erosion was found to be irreversible and correlated with a loss of differentiation characteristics and is very relevant for d

• Recently several clinical trials of stem cell

  2018-10-20

  

  Recently, several clinical trials of stem-cell-based therapy for SCI using either human NS/PCs (Cummings et al., 2005; Salazar et al., 2010) or human ESC-derived OPCs (Strauss, 2010) have been initiated. Compared with these stem cells, iPSCs raise fewer ethical concerns in certain countries (Nori et

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