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Expression profiles from tumor tissue and derived cell lines
2018-10-24
Expression profiles from tumor tissue and derived cell lines are extremely different, thus the current transcriptomic signature for GBM subtyping may not apply in vitro. Using our precursor state signature, we were able to identify an association with the proneural and mesenchymal subtypes. Interest
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We sought to determine whether
2018-10-24
We sought to determine whether T cell-derived iPSCs (TiPSCs) could be used to analyze neurological diseases. Several issues regarding the utilization of TiPSCs in neurological studies remain unresolved. First, previous studies indicated that each iPSC clone retains an epigenetic memory relating to t
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br Results br Discussion Different
2018-10-24
Results Discussion Different routes of reprogramming have been described even when starting with MEFs but these are restricted to late stages of reprogramming and have been demonstrated with different combinations of reprogramming factors (Parchem et al., 2014). Interestingly, recent reports a
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Human pluripotent stem cells hPSCs including human
2018-10-24
Human pluripotent stem buy GS-9973 (hPSCs), including human embryonic stem cells (Thomson et al., 1998) and induced pluripotent stem cells (iPSCs) (Takahashi et al., 2007), provide an ideal in vitro model to recapitulate human hematopoietic development. We have shown that hPSC-derived HSC-like cell
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A better understanding of pluripotent state
2018-10-24
A better understanding of pluripotent state of zebrafish embryos allows us to accurately induce differentiation to cardiomyocytes from primary embryonic cells. A central feature of our method is the use of a combination of appropriate conditions including cell density, ZF4 feeder cells, and suppleme
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Removal of growth factor mediated
2018-10-24
Removal of growth factor-mediated self-renewal signaling in NPC cultures should result in increased expression of terminal differentiation markers (Graham et al., 2003; Sun et al., 2008). Indeed, in 2D monolayer cultures, ReNcell VM increased expression of proteins associated with terminal different
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Another key requirement remains the targeted generation of s
2018-10-24
Another key requirement remains the targeted generation of specific CM subtypes. Successful differentiation into ventricular-, atrial-, or pacemaker-like CM subtypes was mainly investigated using mouse PSCs, but translation to human cells remains a challenge (Birket et al., 2015; David and Franz, 20
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br Results br Discussion Control of cell cycle
2018-10-24
Results Discussion Control of cell-cycle progression has been linked to the regulation of self-renewal and cell-fate determination in ESCs (Pauklin and Vallier, 2013; Singh et al., 2015; White and Dalton, 2005). It has been reported that the length of the G1 phase defines the capacity of multi
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Fig also shows the theoretical dependences
2018-10-24
Fig. 3 also shows the theoretical dependences of the BB-94 of the allowed transitions on the width of InGaAsSb/AlGaAsSb quantum wells at liquid nitrogen temperature. The dash-dot line 1 corresponds to the calculated energy of the transitions between the ground state of heavy holes and the first leve
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br Introduction In the work presented crystals
2018-10-24
Introduction In the work presented, crystals of the silico-sillenite Bi12SiO20 (BSO) doped with Fe3+ ions have been studied. The sillenites are non-centrally symmetrical oxides Bi12MO20±δ (M=Si, Ge, Ti) with the lattice symmetry corresponding to the spatial group I23 [1,2]. In the entirely stoic
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where D is the dose absorbed by the tissue irradiated
2018-10-24
where D is the dose absorbed by the tissue irradiated with the given type of radiation; is the dose required to achieve the same effect with reference radiation. Radiation types whose effect is well-studied can be chosen as reference, for example, hard X-ray radiation (200 − 250kV) or the 60Со rad
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br The quantity is regarded as
2018-10-24
The quantity is regarded as the result of linear extrapolation from two lower time levels: The advantage of this approach for computing the convective term over the one proposed in Ref. [30] is that if the above-mentioned drawback of the Crank–Nicolson scheme emerges, it is possible to switch
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In both the Deep and Upper South regions Blacks in
2018-10-24
In both the Deep and Upper South regions, Blacks in counties with the lowest 1860 slave concentration actually experienced faster mean decline in heat disease mortality than Whites in those same counties (Fig. 2). However, as 1860 slave concentration increased, the rate of decline slows substantiall
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Research from high income countries
2018-10-24
Research from high-income countries posits that provider trainings can improve the specific PPC skills that are linked to patient satisfaction and medical adherence, including encouraging patient participation in decision-making, expressing empathy, asking open-ended questions, and demonstrating reg
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br Methods br Results A total of patients males
2018-10-23
Methods Results A total of 102 patients (69 males and 33 females, 70.1±9.2years) were registered in the study. Baseline clinical characteristics are presented in Table 1. Telomere G-tail length was negatively correlated with aging and positively correlated with total telomere length (ρ −0.287,
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