• Here we examined whether Intracellular ER

  2020-12-30

  

  Here, we examined whether Intracellular ER may mediate Cd-induced ovarian cancer proliferation. To determine this relationship, we used ICI 182,780 as a general inhibitor of ERα and ERβ. The results suggest a metalloestrogenic effect of Cd in ovarian cancer cell lines. Inconsistency with our results

• br Materials and methods br Results and discussion br

  2020-12-30

  

  Materials and methods Results and discussion Conclusions In the present study, we have shown the important role of miR-204-5p in C2C12 myoblast differentiation. Overexpression of miR-204-5p inhibited myogenic differentiation and decreased the formation of slow-twitch myofibers, whereas miR-

• br Materials and methods br Results br Discussion

  2020-12-30

  

  Materials and methods Results Discussion Approximately 90% of pulmonary emphysema causes are related to smoking and its progression in patients and are characterized by severity levels [5]. Experimental models using CS to induce emphysema are widely used because they resemble the emphysema

• From these and other studies it is clear that acriflavine

  2020-12-30

  

  From these and other studies, it is clear that acriflavine is an interesting 796 sale with pleiotropic anticancer effects [21], [22], [43]. Its past systemic use in the clinical setting as an antibiotic without any major toxicity reported encourages further development of the drug for cancer treatm

• DGK negatively regulated the extension of

  2020-12-29

  

  DGKδ negatively regulated the extension of long axon/neurite (Fig. 4, Fig. 5, Fig. 6). The results strongly suggest that deficiency of DGKδ induces OCD-like behavior by enhancing axon/neurite outgrowth. DGKδ positively regulates growth factor signaling (Crotty et al., 2006). Therefore, DGKδ deficien

• Due to its several industrial

  2020-12-29

  

  Due to its several industrial applications, the recombinant production of collagen and all its derivatives as gelatins has been pursued for many years in different biological systems as mammalian Alexidine dihydrochloride (Toman et al., 1999), tobacco plants (Ruggiero et al., 2000), silkworms (Tomi

• A widely accepted mechanism to differentiate hESCs

  2020-12-29

  

  A widely accepted mechanism to differentiate hESCs into cardiomyocytes is through perturbation of the canonical Wnt/β-catenin pathway. Initial Wnt activation is required to form the chk1 [3]. Thereafter, it is believed that inhibition of the canonical Wnt/β-catenin pathway is pivotal for cardiomyoc

• br Introduction Phosphorus P is an important

  2020-12-29

  

  Introduction Phosphorus (P) is an important nutrient for plant growth; however, in many regions of the world soils are low in plant-available P (Holford, 1997). Therefore, P fertilisers play an important role in agriculture. Most P fertilisers in current use are derived from phosphate rock; howev

• In conclusion our data represents a step forward

  2020-12-29

  

  In conclusion, our data represents a step forward in terms of clarifying the role of I/D polymorphism of ACE and VNTR polymorphism of eNOS and G1793A, C677T and A1298C polymorphism of MTHFR in pathophysiology of psoriasis in Pakistani patients. It will help in better understanding of the disease pro

• br Materials and methods br Results br Discussion In additio

  2020-12-29

  

  Materials and methods Results Discussion In addition, the responses of CYP450s induced by metalaxyl are species-specific in the four cells. For example, metalaxyl lead to induction of CYP1A1, CYP1A2, and CYP2B1 in HepG2 cells, CYP1A2 and CYP2B1 in H4IIE cells, CYP1A1 and CYP2B1 in LMH cells

• coelenterazine br Results br Discussion In addition

  2020-12-29

  

  Results Discussion In addition to contributing to amino coelenterazine and lipid biosynthesis, mitochondrial metabolism affects nucleotide biosynthesis. Indeed, many components that contribute to both pyrimidine and purine bases are derived directly or indirectly from mitochondria. Besides gl

• Our results also showed that the highest

  2020-12-29

  

  Our results also showed that the highest dose of Astressin2-B increased the rewarding effects of cocaine, since non-defeated animals treated with this dose developed CPP with a sub-threshold dose. We monitored the acute effects of 30 µg/kg of Astressin2-B and found an increase of anxiety in the open

• The results showed that ethanol

  2020-12-29

  

  The results showed that ethanol and acetaldehyde production was not affected by the presence of CPA-7. We observed that the concentration of ethanol increased throughout the assay up to 95–179 μL L-1 regardless of the treatment. The acetaldehyde concentration reached its highest values after 6–9 day

• Within the X CX PX

  2020-12-28

  

  Within the X1CX3PX5RX7 motif of several prokaryotic FGE substrates, the residues of X3, X5, and X7 are variably found as mixtures of alanine, glycine, threonine, or serine residues [26], [27]. The docked model of our identified HCTPRRP motif revealed that position X1 (H1) and position X7 (P7) were n

• To further investigate mechanisms of

  2020-12-28

  

  To further investigate mechanisms of rXCI, we generated female ESCs with a homozygous RlimKO. We found that these Safingol receptor undergo XCI in vivo but that XCI in vitro is strongly influenced by culture conditions, including both method of differentiation and O2 levels. Our results demonstrate

15778 records 704/1052 page Previous Next First page 上5页 701702703704705 下5页 Last page