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Employing distinct genetic and pharmacological approaches Di
2020-11-17
Employing distinct genetic and pharmacological approaches, Divakaruni et al. now demonstrate that macrophages still acquire their IL-4-elicited phenotype in the absence of CPT1a (considered the main isoform in leukocytes) or CPT2, and highlight that the increased LC-FAO in M(IL-4) cells is less cruc
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Conventional configurations for alkanolamine and acid
2020-11-17
Conventional configurations for alkanolamine and Fmoc-Val-OH gas are not suitable to represent the chemical reaction between acid gas and alkanolamines. Nevertheless, Dowell et al. [17] have successfully represented the phase behaviour of CO2-water-MEA systems by using SAFT-VR [18] without any cons
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br Introduction br Conclusion br Acknowledgments
2020-11-17
Introduction Conclusion Acknowledgments and Funding Introduction Reversible protein phosphorylation is an important post-translational modification of proteins regulating many processes in the cell. Approximately one third of the cellular proteome is phosphorylated, and several sites are
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In conclusion the results obtained in this study
2020-11-17
In conclusion, the results obtained in this study and those recently reported by our group (Abdel-Samad et al., 2012) clearly indicate that a dialogue indeed exists between the systems of NPY and ET-1 at the level of human endocardial endothelial cells, since these cells, whether isolated from the r
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During mouse embryogenesis RLIM protein is
2020-11-17
During mouse embryogenesis, RLIM protein is detectable throughout preimplantation development, consistent with its functions in iXCI maintenance. However, in contrast to differentiating ESCs in culture (Figure 2A), RLIM protein levels are downregulated in nuclei of epiblast cells of implanting embry
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br Methods Ventricular cardiomyocytes from adult male
2020-11-17
Methods Ventricular cardiomyocytes from adult male Wistar rats were isolated using a standard enzymatic digestion [11]. Cells were incubated at 37°C for 4 to 6h with Tyrode solution (in mM: 140 NaCl, 4 KCl, 1.1 MgCl2, 10 HEPES, 10 glucose, 1.8 CaCl2; pH7.4, with NaOH) supplemented or not with 10μ
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br DDR receptor and MMP expression Type II collagen
2020-11-16
DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix of mature articular cartilage once the collagen gets disrupt
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Despite the weak and transient nature of
2020-11-16
Despite the weak and transient nature of E2–E3 interactions, this binding is required for the transfer of ubiquitin to the substrate. The low affinity characteristics of this interaction may be due to the fact that E2s use the same surface to interact with E1s and E3s, and hence while binding to an
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Inflammatory action of certain cytokines can influence
2020-11-16
Inflammatory action of certain cytokines can influence cell proliferative routes (Deshmane et al., 2009). When mTOR is inhibited, for instance by the action of Rapa, TGF-β1, which has an anti-inflammatory action, is increased. The relationship between high levels of TGF-β1 and BMS354825 arrest has
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br GPCRs form heterotetramers In addition to
2020-11-16
GPCRs form heterotetramers In addition to homodimers and heterodimers, for several family A receptor heteromers, experimental evidence supports the presence of higher order rearrangements as tetrameric structures, comprised of two different homodimers, each able to signal with its preferred G pr
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Why then is leading strand DNA synthesis reduced
2020-11-16
Why then is leading-strand DNA synthesis reduced relative to lagging-strand synthesis in rad53-1 mutant SP 600125 under replication stress? To gain insight into this question, we first determined whether the firing of late origins in rad53-1 mutant cells contributes to compromised leading-strand sy
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The acids applied in this study
2020-11-16
The acids applied in this study are commonly used in dental practice. Phosphoric iap apoptosis is an oxyacid used regularly for adhesion of resin composites. Enamel phosphoric acid etching can dissolve and demineralize the inorganic [Ca10(PO4)6(OH)2] matrix, creating micro pores and microgrooves to
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br Conclusions In this paper we describe the recombinant exp
2020-11-16
Conclusions In this paper we describe the recombinant expression and characterization of ParI, a C5-DNA-MTase from P. arcticus 273–4. To our knowledge, this is the first characterization of an orphan C5-DNA-MTase from a psychrophilic bacterium. The C5-DNA-MTase could not be expressed in regular E
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br Materials and methods br Results br Discussion In
2020-11-16
Materials and methods Results Discussion In this study, we developed a new CysLT1 and CysLT2 receptors-mediated Norethindrone australia guinea pig model for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. Unlike human CysLT2 receptors, which are equally stimulated by both
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In recent years the use of liquid chromatography tandem
2020-11-16
In recent years, the use of liquid chromatography/tandem mass spectrometry (LC–MS/MS) has become a preferred approach to measure drugs and metabolites in biological fluids due to its very high selectivity and sensitivity [17], [18], [19], [20], [21], [22], [23], [25], [30]. The great sensitivity of
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