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Based upon these findings on portions A
2020-11-25
Based upon these findings on portions A and B, novel scaffolds of EP4 antagonist, and (R & R=()-Me; =Cl; R=H), shown in , were identified. We next focused on optimizing portion C of these scaffolds. We utilized for an alternative synthesis of nicotinamide scaffold , which is quite effective for der
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In a larger study of patients
2020-11-25
In a larger study of 22 patients with nondiabetic proteinuric chronic kidney disease, BQ-123 produced significant natriuresis, resulting from increased renal blood flow. In addition, ETA antagonism reduced blood pressure and proteinuria, and, a new finding, decreased arterial stiffness. However, in
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br Introduction As a serine proteinase and a sub family
2020-11-25
Introduction As a serine proteinase and a sub-family of the chymotrypsin-like proteinase, Glutamyl endopeptidase (GE), which is mainly found in Bacillus species, specifically cleaves negatively charged amino in fact residues (Glu/Asp) (Yokoi et al., 2001). Madsen et al. (Madsen & Qvist, 1997) re
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Therefore HNE is an attractive
2020-11-25
Therefore, HNE is an attractive therapeutic target and the design of new HNE inhibitors is a demanding field that has been extensively investigated in order to provide inhibitors with new molecular architectures, including the potent oxo-β-lactam class [14]. In the present work, a coumarin-based oxo
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br DDR mediated signaling DDRs
2020-11-25
DDR-mediated signaling DDRs initiate signaling pathways in a context and cell type-dependent manner. For instance, DDR1 was reported to activate ERK in vascular smooth muscle Caspase-9 Colorimetric Assay Kit (Lu et al., 2011), to inhibit ERK in mesangial cells (Curat and Vogel, 2002), and to ha
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Expression of EBI and its function for migration in vitro
2020-11-25
Expression of EBI2 and its function for migration in vitro in T cells was recently reported (Chalmin et al., 2015, Hannedouche et al., 2011, Liu et al., 2011, Pereira et al., 2009). Pereira et al. (2009) used an EBI2 reporter mouse and found that most CD4+ T cells, but only approximately half of the
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Why are Tfh cell dynamics so fundamentally
2020-11-25
Why are Tfh cell dynamics so fundamentally different in naive and immune animals? Initially, GC Edoxaban must pass stringent affinity and specificity checkpoints to ensure only high-affinity non-self-reactive cells are selected. Therefore, restricting primary Tfh cells with the greatest helper capac
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Muscle Ring Fingers MuRFs comprising TRIM MuRF
2020-11-25
Muscle Ring Fingers (MuRFs) comprising TRIM63 (MuRF1), TRIM55 (MuRF2) and TRIM54 (MuRF3) are the most studied TRIMs in the heart. However, with increasing knowledge of E3 ligases and recent advancements in the field, many other TRIMs such as TRIM8, TRIM21, TRIM24, TRIM32, TRIM45, TRIM69 and TRIM72 w
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Similarly synthetic analogs of Alogliptin by replacing the c
2020-11-25
Similarly synthetic analogs of Alogliptin by replacing the cyanobenzyl group with the butynyl group have been synthesized and tested as selective DPP-4 inhibitors [7], [8]. Additionally, quinazolines [9], [10], pyridopyrimidinediones [11], pyrazolopyrimidinones [12] and pyrimidines [13] as DPP-IV in
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br Materials and methods br Results br Discussion
2020-11-25
Materials and methods Results Discussion The present study shows that 1) overexpression of wild-type or mutant α-SYN interferes with forskolin-induced DBH up-regulation, 2) α-SYN enters into the nucleus and is able to bind to CRE region, compete for CREB, and attenuate CRE-mediated transcri
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Several DA receptors heteromers with a therapeutic potential
2020-11-25
Several DA receptors heteromers with a therapeutic potential have been described, including D1R/D3R (Fiorentini et al., 2010), but their roles remain to be established. Moreover, most studies on receptor heteromers in addiction focused on the striatum because of its key role in the pathology and its
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br Conflict of interest br Acknowledgements This
2020-11-25
Conflict of interest Acknowledgements This work was supported by the Biotechnology Research Center, China Three Gorges University, Yichang, China (No. 2016KBC05), the National Natural Science Foundation of China (No. 31370600 and 31300508), the Zhejiang Science and Technology Major Program on
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In astrocytes mitogen activated protein kinases MAPKs
2020-11-25
In astrocytes, mitogen-activated protein kinases (MAPKs) are activated after OGD-induced ischemic injury (Yung and Tolkovsky, 2003, Niu et al., 2009) and they regulate induction of AQP expression (Arima et al., 2003, McCoy and Sontheimer, 2010). It is well known that MAPKs, including extracellular s
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We hypothesized that the atopic
2020-11-25
We hypothesized that the atopic phenotype may be partially influenced by an altered binding and/or signalling due to the amino-acid substitution in the receptor protein. The principal aim of this study was to investigate the signalling mechanisms of the variants CysLT1-G300S and CysLT1-I206S induced
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Within the Class II receptors the Type
2020-11-24
Within the Class II receptors, the Type I IFN receptor subunit, IFNAR-1, is exceptional in having four tandem FNIII domains, denoted here D1–D4. This structure appears to have arisen as a tandem TAME of the basic D1/D2 structure; thus, D1 and D3 of IFNAR-1 are more closely related, as are D2 and D4
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