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The present findings demonstrate for
2021-10-12
The present findings demonstrate for the first time in immature rats that hippocampal infusion of ET-1 results in a rapid and long-lasting decrease in regional cerebral blood flow (rCBF) and oxygen saturation (pO2). These data are in accord with the results of studies and adult animals, which have s
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A pyrimidine class of compounds is of enormous interest
2021-10-12
A pyrimidine class of compounds is of enormous interest within anti-HIV drug discovery process for several decades, as pyrimidine based DABOs class [7], DAPYs class [8] are well known as NNRTIs as well as NRTIs. However, the overall role of a pyrimidine class of heterocycles in anti-HIV drug discove
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have to happen to you br Conclusion br Author contributions
2021-10-12
Conclusion Author contributions Ethics approval Competing interests Introduction VHL is a well-known tumor suppressor and works as a target recruitment subunit of an E3 ubiquitin ligase complex that recruits hydroxylated hypoxia inducible factor α (HIF-α) for proteasomal degradation u
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br Introduction The airway epithelium is the
2021-10-12
Introduction The airway epithelium is the first barrier against inhaled insults and the final barrier against internal forces (hydrostatic, inflammatory, and ischemic) that disrupt water and solute movement across the epithelium. This barrier is formed by adhesion of airway and alveolar epithelia
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Given the role that activation
2021-10-12
Given the role that activation of GC-C has in stimulating fluid secretion in the intestine, attempts have been made to exploit this pathway to relieve symptoms of chronic constipation. Currently, an orally administered synthetic ST mimic, linaclotide [29], has been successfully shown to alleviate co
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The opposite modulation observed for circulating LPI levels
2021-10-12
The opposite modulation observed for circulating LPI levels and WAT GPR55 2825 australia by nutritional status suggests that increased levels of LPI may down-regulate the expression of its receptor in WAT, whereas in conditions of low serum LPI levels, the expression of GPR55 is stimulated. However,
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Several studies have proposed that high levels of
2021-10-12
Several studies have proposed that high levels of KYNA in the dna methyltransferase contribute to cognitive dysfunctions presented by patients who suffer from schizophrenia [30], [31], [32], [33]. Considering that: (i) KYNA is a known GPR35 agonist [2], (ii) cognitive impairments in patients with s
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Finally we investigated if calpain truncation affects GlyT
2021-10-12
Finally, we investigated if calpain truncation affects GlyT1 turnover and trafficking. To simulate calpain cleavage at the T602/T603 and G626/S627 sites we constructed GlyT1 transporters missing the last 12 and 36 amino acids. Since the 36 amino ro5 truncation also removes all C-terminal antibody e
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br Acknowledgements This research was funded by Ministry of
2021-10-12
Acknowledgements This research was funded by Ministry of Education Malaysia (MOE), and supported by the Department of Nutrition, Exercise & Sports, Department of Drug Design, University of Copenhagen, Denmark and Universiti Malaysia Pahang (UMP), Malaysia. HPLC equipment used for high-resolution
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MAPK are involved in a large variety of solid
2021-10-11
MAPK are involved in a large variety of solid and hematolgical neoplasms and, indeed, several components of the MAPK network have already been proposed as targets in cancer therapy, such as p38, JNK, ERK1/2, MEK1/2, RAF, RAS, DUSP1 and ERK5 [11], [12]. Among them, alteration of the RAS-RAF-MEK1/2-ER
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Seizures in turn selectively modulate the expression of
2021-10-11
Seizures, in turn, selectively modulate the AZD2858 of GalR in the hippocampus. Thus, pilocarpine-induced SE led to a 30% downregulation of GalR2 without affecting GalR1 (personal communication with T. Bartfai, Scripps Research Institute). Therefore, despite the fact that GalR2 could have been a mo
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br Introduction Farnesoid X receptor FXR is
2021-10-11
Introduction Farnesoid X receptor (FXR) is a bile Exendin-3 (9-39) amide regulated nuclear receptor highly expressed in the liver, intestine, kidney and adrenal glands in rodents.1, 2, 3, 4 FXR regulates transport proteins, the bile salt export pump (BSEP) and the organic solute transporter α (O
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Carprofen br Materials and methods br Results
2021-10-11
Materials and methods Results and discussion To analyze the dependence of lysosomal exocytosis on Cu we exposed HeLa Carprofen to fresh buffer containing normal levels of free Ca (1mM) and measured β-hex levels in the extracellular medium, followed by measuring β-hex content in the total cell
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br Conclusions Histone acetylation deacetylation is
2021-10-11
Conclusions Histone acetylation/deacetylation is a major epigenetic mechanism implicated in the regulation of transcription and various biological processes such as development and gametogenesis from plants to vertebrates. However, despite being well characterized in zebrafish, acetyltransferase
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Utilization of fascinating properties such as localized surf
2021-10-11
Utilization of fascinating properties, such as localized surface plasmon resonance (LSPR), high fluorescent quantum yield, biocompatible nature, chromogenic and electrocatalytic functionality of several nanomaterials for histamine sensing is also quite evident where the nanomaterials have served as
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