• The present study determined the effect of DCA on VSMC

  2024-12-05

  

  The present study determined the effect of DCA on VSMC calcification in vitro and in atherosclerotic ApoE-/- mice in vivo. We found that Viomycin non-toxic concentrations of DCA, did not affect VSMC viability, induced calcification of VSMC in culture and increased atherosclerotic vascular calcifica

• Taken together the results reveal a complex feedback

  2024-12-05

  

  Taken together, the results reveal a complex feedback and feedforward signaling network between the tryptophan metabolic enzymes IDO1/TDO2, the KP metabolite KYN, and the ligand-activated transcription factor AhR (Figure 2). Cancer Liraglutide highjack this signaling circuitry to deregulate immunol

• stain gel Patients with ADA SCID may experience autoimmune

  2024-12-05

  

  Patients with ADA-SCID may experience autoimmune AEs after SCT (and/or during ERT) that are thought to be related to immune dysregulation prior to achieving complete immune reconstitution. The more common autoimmune manifestations include hemolytic anemia, hypothyroidism, and immune thrombocytopenia

• br COPD As in asthma also in COPD increased

  2024-12-04

  

  COPD As in asthma, also in COPD, increased expression of arginase has been reported, and tobacco smoke may increase expression of arginase in human subjects [46, 47]. Increased ADMA levels have also been reported in COPD, and both the increased expression of arginase and ADMA contribute to remode

• br Experimental and simulation section br Acknowledgments Fi

  2024-12-04

  

  Experimental and simulation section Acknowledgments Financial support for this work was provided by the National Natural Science Foundation of China (No. 81101688). We would like to thank NC State University High Performance Computing Center for providing us computing resources, and Dr. Lihui

• Besides above mentioned UV visible and

  2024-12-04

  

  Besides above-mentioned UV–visible and fluorescence spectroscopy methods, electron paramagnetic resonance (EPR) spectroscopy, the only analytical method that detect compounds having unpaired electrons known as free radicals, was rarely used in antioxidant capacity measurement (Amarowicz et al., 2004

• Echinocandin resistance is systematically associated with po

  2024-12-04

  

  Echinocandin resistance is systematically associated with point mutations in either FSK1 or FSK2 genes [7], [104]. These mutations are located in two different not spot regions of these genes named HS1 and HS2. Hot spot mutations have been reported in C. albicans, C. glabrata, C. tropicalis, C. krus

• Further validation for a role in LOX pathway in

  2024-12-03

  

  Further validation for a role in 12/15-LOX pathway in mediating adipocyte function comes from studies revealing a regulatory role of lipocalin-2 on 12/15-LOX activity. Lipocalin-2, a glycoprotein member of the lipocalin superfamily, is a novel abundant adipokine implicated in obesity-mediated inflam

• br Material and methods br Results br

  2024-12-03

  

  Material and methods Results Discussion RSV is a major cause of lower respiratory tract infections in infancy and early childhood. Several observations suggest that immunological mechanisms may be the key to understand the severity of RSV bronchiolitis in infancy. Several laboratories have

• Cancers that responded to immune checkpoint inhibitors were

  2024-12-03

  

  Cancers that responded to immune checkpoint inhibitors were shown to present a type I interferon (IFN) signature in the TME 33, 34. Type I IFNs positively regulate the expression of tumor antigens and their crosspresentation by DCs to tumoricidal CTLs. Furthermore, CD8+ T cell develops full effector

• Thyroid Hormone Receptor Antagonist (1-850) br Theoretical m

  2024-12-03

  

  Theoretical mechanism of ABCA2 activity in LE/LY in modulation of cholesterol trafficking It is important to confirm that ABCA2 is a lipid transporter and identify the substrates that are mechanistic in its cholesterol sequestering activity. We hypothesize that ABCA2 modulates cholesterol sequest

• The results also showed that

  2024-12-02

  

  The results also showed that the A3 receptor agonist increased the phosphorylated levels of Akt, leading to activation of the PI3K/Akt pathway. A3 Macitentan synthesis stimulation has protective effects against RGC death following ischemia-reperfusion, glutamate toxicity, and optic nerve transectio

• br New AMPK activators Fenofibrate is a

  2024-12-02

  

  New AMPK activators Fenofibrate is a drug of the fibrate class used for the treatment of dyslipidemia [53] but is also an agent that could alleviate DN-induced alterations through AMPK activation (Fig. 2). Streptozotocin-induced diabetic rats treated with fenofibrate improved in not only renal fu

• NOXA a BH only protein

  2024-12-02

  

  NOXA, a BH3-only protein, is best known as a selective inhibitor of MCL-1, which is a highly expressed pro-survival protein in many human malignancies [30]. In addition, NOXA was recently proven to act as a direct activator via directly binding to BAX to induce apoptosis [31]. Given that its levels

• 5,7-dihydroxychromone br Conflict of interest br Acknowledgm

  2024-12-02

  

  Conflict of interest Acknowledgments This work was financially supported by the Fund Project of Sichuan Provincial Department of Education (16ZB0053), the Scientific Research Foundation of Sichuan Agricultural University (No. 06021400) and the China Postdoctoral Science Foundation (No. 2015M58

15858 records 46/1058 page Previous Next First page 上5页 4647484950 下5页 Last page