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Functional enhancers are often composed
2024-07-06
Functional enhancers are often composed of binding motifs of multiple key transcription factors to confer spatial and temporal regulation of genes in a certain context. In the uterus, the difference between the number of genes that have associated PGR occupancy and that of progesterone responsive ge
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Coincident with APJ receptor several
2024-07-06
Coincident with APJ receptor, several cell types in the body can synthesize apelin protein. For example, the highest apelin concentrations in the body have been found in the rat central nervous system, pituitary gland, lungs, cardiac muscle, gastrointestinal tract and mammary glands, with lower valu
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It has been proven that genetic
2024-07-06
It has been proven that genetic polymorphisms can play an important role in development of hypertension and CVDs. In a Turkish population-based study, it was found that the APLNR gene (rs948847-A445C) polymorphism was not associated with coronary artery disease (CAD), but it was shown to be related
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br Conclusion br Introduction Breast cancer is the most
2024-07-06
Conclusion Introduction Breast cancer is the most common cancer and second leading cause of cancer-related deaths in women [1,2]. There were about 1.7 million new cases of breast cancer worldwide in 2012 [3], and the number of new cases of female breast cancer is expected to increase to 3.2 mi
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Although the gene that encodes DHFR
2024-07-06
Although the gene that encodes DHFR has been strongly conserved during evolution, subtle differences in the active sites of bacterial, human and parasite LIMKi 3 have been exploited to develop DHFR inhibitors specific to particular pathogens 1, 3. For example, pyrimethamine and cycloguanil bind str
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Glycosylphosphatidylinositol GPI cell wall anchor synthesis
2024-07-06
Glycosylphosphatidylinositol (GPI) N6-methyladenosine anchor synthesis pathway is another promising antifungal target. Novel inhibitors of Gwt1 and Mcd4, two enzymes in the GPI anchor pathway were identified by the chemical-genomics-based screening platform CaFT (Candida albicans fitness test) [89]
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To the best of our knowledge there
2024-07-06
To the best of our knowledge, there have been only a few reports on antiangiogenic activities about C. sanki, and its antiangiogenic constituents as well as its mechanism of action are worthy of further exploring and studying. Therefore, we carried out a bioassay-guided investigation of C. sanki in
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Another class of AMPK regulator is peptidyl prolyl cis
2024-07-06
Another class of AMPK regulator is peptidyl-prolyl cis/trans isomerase (PPIase) NIMA-interacting 1 (Pin1), which binds to a number of proteins and regulates oncogenesis and metabolic diseases (Khanal et al., 2013; Zhou and Lu, 2016). Pin1 has been shown to bind to and inhibit AMPK; therefore, at lea
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br Conclus o br Conflitos
2024-07-05
Conclusão Conflitos de interesses Alzheimer Disease: Common and Complex Alzheimer’s disease (AD) is a genetically complex, multifactorial disease that leads to neurodegenerative dementia. There is no cure for AD yet, and due to a high prevalence and continuously increasing incidence it pose
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Additionally we were prompted to validate
2024-07-05
Additionally, we were prompted to validate the protective effect of ALDH3A1 by utilizing a human corneal model. Cornea is located in the anterior segment of the eye and thus, is constantly exposed to various environmental stressors that affect the cellular oxidative balance and consequently lead to
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In this study Rb increased the phosphorylation of p
2024-07-05
In this study, Rb1 increased the phosphorylation of p38 MAPK and Akt and macrophage phagocytosis of bacteria in mouse lung cells, consistent with the in vitro results. A recent study showed that Rb1 diminished the severity of lung injury in rats exposed to LPS. Rb1 inhibited the LPS-induced increase
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The indirect effect of corporate taxation
2024-07-05
The indirect effect of corporate taxation, as given by the second term in Eq. (18), consists of two elements; (i) a standard Myosmine effect (τ/n2), and (ii) a capital cost effect (rG(1−αt)/(1−t)). With a CRS technology, the cost effect vanishes, whereas with an IRS (a DRS) technology the cost effec
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br Funding This study was supported by Grant
2024-07-05
Funding This study was supported by Grant UM1-CA186690 (NCI-CTEP) and R01CA204173 (CJB). This project used the UPCI Cancer Pharmacokinetics and Pharmacodynamics Facility (CPPF) and was supported in part by award P30-CA47904 and R50CA211241. Introduction Despite the efficacy of platinum based
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Why do glutamate and glycine bind to the receptor in
2024-07-05
Why do glutamate and glycine bind to the Isochlorogenic acid B in such different ways? Given the overall structural similarity between the GluN2A and GluN1 LBDs, one might conclude that the LBDs also bind ligands via similar processes. NMDA receptors with engineered disulfide linkages that lock the
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Secondly leptin has been shown to enhance
2024-07-05
Secondly, leptin has been shown to enhance aromatase mRNA expression, aromatase content and its enzymatic activity in epithelial breast cancer AR-13324 by inducing promoters II and I.3 via an enhanced binding of transcription activator protein 1 (AP-1) complex to specific DNA sites in the promoter r
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