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GPR is a G protein coupled receptor that has pro
2022-04-08
GPR55 is a G protein-coupled receptor that has pro-oncogenic properties and whose expression correlates with tumor aggressiveness and increased activation of extracellular signal-regulated kinase (ERK) cascade [12]. Elevated expression of GPR55 has been linked to aggressiveness in human pancreatic,
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This study does have important limitations
2022-04-08
This study does have important limitations to consider. The utilization of a recombinant gp120 monomer (at a single concentration of 100 ng/ml) instead of live virus particles may limit the validity of our results. Moreover, extrapolation of an in vitro cell culture model to animals or humans cannot
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It is possible that maternal separation induced USV
2022-04-08
It is possible that maternal separation-induced USV in neonatal rodents is not a good model of adult anxiety for examining GlyT1 inhibitors, if the expression levels of GlyT1, GlyA, and GlyB markedly differ between pups and adults. However, several reports provide evidence that this is not the case.
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Morin is a flavonoid that has shown to
2022-04-08
Morin is a flavonoid that has shown to have effective anti-inflammatory and anti-tumor function [118]. Morin was able to block the activation of NF-κB pathway by ROS and inflammatory cytokines, preventing a signaling cascade resulting in cell death [121]. Morin exerted its control over the signaling
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P gps expressed in cells and tissues of human
2022-04-08
P-gps, expressed in VEGFR Tyrosine Kinase Inhibitor II australia and tissues of human and animals, play an active role in cellular protection against multiple toxicants by transporting them out of a cell. Thus, improving transport activity of P-gp may contribute to removing Cd from living oysters.
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br Introduction Given the growing acceptance of ergothionein
2022-04-08
Introduction Given the growing acceptance of ergothioneine (ET) as a biologically important agent with potential therapeutic applications [[1], [2], [3], [4]] it is increasingly important to clearly establish the role of the organic cation transporter (novel) type 1 (OCTN1). OCTN1 was discovered
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br Regulation of Glu transporters
2022-04-08
Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino dpp-4 inhibitors calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include tra
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The monomer composition and the variation in the cryogelatio
2022-04-08
The monomer composition and the variation in the cryogelation process can result in cryogels with slightly different properties. The adequate characterization of these matrices is advisable in the studies aiming a better understanding of flow inside its structure and also the interactions between th
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The relationship between estrogen and the
2022-04-08
The relationship between estrogen and the Hedgehog pathway as well as the associated mechanism have already been investigated in many tissues, especially in breast cancer (Chang et al., 2012, Katayama et al., 2006, Ramaswamy et al., 2012). Hitherto, even though we have proved that HH-Gli pathway pro
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br Methods br Results br Discussion
2022-04-08
Methods Results Discussion The measurement of intraocular pressure was made with a commercially available rebound tonometer, the Tonovet®. In our studies, Tonovet® underestimated the intraocular pressure in both animal models, being this effect more pronounced in the rat. To study the effe
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Gastrodin The identity of the K
2022-04-08
The identity of the K+ transport pathway activated by NEM remains unclear. The pathway does not require the presence of Gardos channel KCNN4 or K–Cl cotransporters KCC3 and KCC1, but like these pathways is sensitive to the presence of hemoglobin S or other sickling hemoglobins. Although partially se
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br Conclusion In conclusion rats in this model
2022-04-07
Conclusion In conclusion, rats in this model of HELLP syndrome demonstrated increased placental and circulating FasL and increased placental Fas when compared to NP rats. Administration of an ETA receptor antagonist to HELLP rats tended to decrease circulating FasL and placental Fas, while not af
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The even bigger surprise was the second feature
2022-04-07
The even bigger surprise was the second feature of both structures. Interestingly, binding of the MRG domain hardly altered the conformation of the SET domain compared with its apo state (An et al., 2011). What did change, however, is the conformation of the ASH1L auto-inhibitory loop (Figure 1). De
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Materials and methods br Results and discussions br Conclusi
2022-04-07
Materials and methods Results and discussions Conclusions In this study, we identified 7 histone acetyltransferases and 12 histone deacetylases in Marchantia polymorpha. The present phylogenetic analysis of MpHATs and MpHDACs provide the insight into the evolutionary relationships of these tw
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Almost all of the series
2022-04-07
Almost all of the series and compounds exhibited higher activities compared with the compounds in the other series. In these series, the tetrazole group was directly linked to a nitrogen atom of the amide group at the C-28 position, and the C-3 hydroxy group was either unmodified, oxidized, esterifi
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