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Gene expression of both GPR A
2022-04-22
Gene expression of both GPR109A and GPR81 in adipocytes has been linked to PPARγ activation [22]. Treatment with the thiazolidinedione (TZD) PPARγ agonist, rosiglitazone, increases GPR109A and GPR81 expression, and knockdown of PPARγ suppresses receptor expression in fully differentiated human multi
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Niacin nicotinic acid is widely used to regulate abnormaliti
2022-04-22
Niacin (nicotinic acid) is widely used to regulate abnormalities in plasma lipid and lipoprotein metabolism, as evidenced by its potential for reducing atherosclerotic cardiovascular disease risks (Guyton, 1998), due to its ability to reduce circulating triglycerides and apolipoprotein-B containing
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In this study we find that DH CBD
2022-04-22
In this study, we find that DH-CBD induces analgesic effects on inflammatory but not acute pain and the BRD-6125 receptor level of spinal α1 GlyRs increased after CFA paw injection. These results suggest that GlyR α1 is only involved in chronic pain. A possible explanation is that once the expressi
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C527 FFAR is highly expressed not only in cells but
2022-04-22
FFAR1 is highly expressed not only in β cells but also in α C527 (Segerstolpe et al., 2016), which gives the interesting perspective that 20-HETE may function both as an autocrine and as a paracrine regulator of islet cell function (Figure 1A), i.e., acting in symphony with the many other intra-isl
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br Materials and methods br Results br Discussion
2022-04-21
Materials and methods Results Discussion In this study, we demonstrated, for the first time, that manipulation of AKR1D1 expression and activity is able to regulate glucocorticoid availability in liver and non-liver cell lines. AKR1D1 over-expression leads to increased glucocorticoid cleara
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br Methods br Results br Discussion In this
2022-04-21
Methods Results Discussion In this series of studies we hypothesized that FHH-GHSRm1/Mcwi rats would, relative to their WT counterparts, exhibit a metabolic and behavioral phenotype reminiscent of GHSR−/− mice. Through the use of the GHSR−/− mouse, a great deal about the role of ghrelin sig
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In a mouse model of hyperhomocysteinemia a risk factor for
2022-04-21
In a mouse model of hyperhomocysteinemia (a risk factor for the development of vascular dysfunction) it has been shown that myoendothelial communication is enhanced due to increased expression of Cx37 and IK1 Netilmicin Sulfate [], allowing the propagation of endothelial signals to VSMC and thereby
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Analgesic activity was evaluated by measuring tail flick lat
2022-04-21
Analgesic activity was evaluated by measuring tail flick latencies to the immersion of rat’s tail in water, maintained at ∼51°C [18] after recovery from anesthesia. Typically, rats were immobilized inside a restrainer, leaving only the tail exposed, which was then immersed into the hot water bath, a
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The intestinal epithelium is the first line of defense again
2022-04-21
The intestinal epithelium is the first line of defense against pathogens and noxious agents and exerts a range of physiological activities, including digestion and Metronidazole receptor of nutrients. The intestinal wall consists of a series of finger shaped protrusions called villi and invaginatio
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The second patient had a homozygous
2022-04-21
The second patient had a homozygous substitution within exon 6 (c.538C>T). The parents were heterozygous and showed no clinical or immunological defect. The mutation has been predicted to alter a potential exonic splicing enhancer (ESE) site. Therefore, exon 6 skipping could be explained by the ESE-
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Following the discovery of diketo compounds S and L
2022-04-21
Following the discovery of β-diketo compounds S-1360 [31] and L-731988 [32] as anti-HIV integrase inhibitors, a group of researchers discovered a potent bupropion hydrochloride receptor based derivative (1) as the inhibitor of HIV integrase functioning at the 3′-processing and strand transfer steps
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This study was supported by
2022-04-21
This study was supported by the Finance Department Foundation of Jilin Province (3D5178963428). Introduction Breast cancer is one of the leading cause of death in women worldwide [1,2]. Due to recent advances of combined therapies, survival rate of breast has improved significantly. However, bre
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In our previous study we designed and synthesized compounds
2022-04-20
In our previous study, we designed and synthesized compounds of A series from the starting material 4-hydroxy-3-methoxycinnamic Norfloxacin (ferulic acid). These compounds with R group being amino acid residues, fatty acyl group and sulfuryl group showed moderate HDAC inhibition and in vitro antitu
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It has been reported that expression of
2022-04-20
It has been reported that expression of murine haspin is found only in post-meiotic spermatids and that overexpression of murine haspin in HEK-293 cells leads to reduced cell proliferation. Therefore, it was suggested that haspin functions to bring about cyclosporin arrest in haploid germ cells (Ta
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Financial nonfinancial disclosures The authors
2022-04-20
Financial/nonfinancial disclosures: The authors have reported to CHEST the following: M. J. A. has received investigator-initiated grants from Pfizer and Boehringer Ingelheim for unrelated research. None declared (X. D., S. C. D., G. B., N. T. W., J. L. P., J. H., B. E., A. J. L., J. A. B., C. S., C
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