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br Introduction It is well
2024-07-25
Introduction It is well known that when epithelial cells are deprived of anchorage, they undergo detachment-induced apoptosis, also known as anoikis. Cancer cells, by contrast, are able to suppress anoikis and survive under anchorage -independent conditions in the circulating system, which is tho
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br Discussion To our knowledge this is
2024-07-24
Discussion To our knowledge, this is the first case report that demonstrates the presence of a novel T1151K ALK mutation in a patient with disease progression after crizotinib and then ceritinib. As early as 2011, Zhang et al. identified T1151K among other resistance mutations to crizotinib in Ba
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Cancer stem cells CSCs may have been first identified
2024-07-24
Cancer stem cells (CSCs) may have been first identified in teratocarcinomas [11], [12], with its initial clues date back to the 19th century [13]. Kleinsmith and Pierce [12] established the immortal pluripotent teratocarcinoma lines from a single transplanted multi-potent malignant cell, strongly su
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br Conclusion br Conflict of interest
2024-07-24
Conclusion Conflict of interest Introduction Oral cancer may originate from lips, lower and upper alveolar ridges, hard palate, sublingual region, buccal mucosa, anterior two-thirds of the tongue as well as retromolar trigone and floor of the mouth (World Health Organization, 2013). As the
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The role of circulating physiologic concentrations of FGF in
2024-07-24
The role of circulating physiologic concentrations of FGF21 in glucose metabolism, however, remains unclear. Circulating FGF21 levels in obese and diabetic rodents, and in patients with type 2 diabetes are significantly higher than those in controls without diabetes [4], [5], [6]. On the other hand,
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br Acknowledgments This work was supported by the
2024-07-24
Acknowledgments This work was supported by the R&D Program of the Institutional Research Program of KRICT (SI1701-02), and by the Next generation carbon upcycling project of Ministry of Science and ICT. JSC is kindly grateful to the National Research Council of Science and Technology (NST) for fi
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In addition to the above mentioned synaptic mechanisms
2024-07-24
In addition to the above-mentioned synaptic mechanisms, the serotonergic system also has a critical role in the antidepressant effects of mGlu2/3 receptor antagonists. Indeed, we previously reported that mGlu2/3 receptor antagonists increased the firing rate of serotonin neurons in the dorsal raphe
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In young animals the HT A
2024-07-24
In young animals, the 5-HT2A Aloperine antagonist ketanserin, at relatively low concentrations, shifted 5-HT concentration-response curves rightward, suggesting a role for 5-HT2A receptors in mediating 5-HT-induced contractions of the ureter. The slopes of the ketanserin Schild plots for the antago
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Based on currently available knowledge
2024-07-24
Based on currently available knowledge, autophagy supports adipocytes development and differentiation. In animals with specific skeletal muscle Gadodiamide receptor of Atg7, reduced adipogenesis was shown. In rodents, autophagy was decreased in adipose tissue of animals fed with high-fat diet (HFD)
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Production of reactive oxygen species ROS during RSV infecti
2024-07-24
Production of reactive oxygen species (ROS) during RSV infection is one the important ways that neutrophils can injure the lungs [2], [24], [25]. Lipoxygenases are considered as an important source of producing ROS inside the Tobramycin [26]. Several studies have indicated that the 12/15-LOX is a p
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Previous studies have indicated that maximal IL protein expr
2024-07-23
Previous studies have indicated that maximal IL-8 protein Pifithrin-μ requires NF-κB activation as well as the activation of the MAP kinases ERK, JNK, and p38 (Li et al., 2002). In our study, NF-κB inhibitor can reduce the up-regulated IL-8 production by PRRSV infection, indicating that PRRSV-induc
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Introduction Antimicrobial resistance is a growing health
2024-07-23
Introduction Antimicrobial resistance is a growing health threat worldwide that has been associated with incorrect prescription and overuse of glibenclamide [1]. Considering that physicians play a central role in antibiotic usage, a better understanding of their prescribing behaviours and their kno
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br HIF Signaling in AA Therapy Resistance An
2024-07-23
HIF-α Signaling in AA Therapy Resistance An important result emerging from Phase 3 clinical trials testing AA therapies is improvement of progression-free survival (PFS) that is not accompanied by enhanced overall survival (OS) [26]. This dichotomy has been attributed to mechanisms of acquired re
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br Animal models of NAFLD Human research has
2024-07-23
Animal models of NAFLD Human research has greatly shaped our understanding of non-alcoholic fatty liver disease, but several limitations exist in studying the disease processes in humans, such as variations in environmental exposure, pre-existing genetic risk factors, racial and ethnic difference
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When a clinician diagnoses a person with AD the person
2024-07-23
When a clinician diagnoses a person with AD, the person is transformed into a patient with the disease. The person is a member of a patient group associated with behaviors, abilities, and experiences related both formally and informally to the diagnosis [10]. The diagnostic label implies what signs
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