• Our study has some limitations that

  2022-09-30

  

  Our study has some limitations that should be considered when the results are interpreted. First, we did not measure the protein levels of Bax and Bcl2, due to time and budget limitations. Although simultaneous measurements of both mRNA and protein levels are complementary for a better understanding

• It is generally considered that elevated blood glucose

  2022-09-30

  

  It is generally considered that elevated blood glucose due to insulin resistance is an important factor in islet compensation to high fat feeding [27]. However, we have shown recently that insulin resistance induced in mice by hydrocortisone injection provokes significant islet Aliskiren Hemifumarat

• Tianeptine sodium br Results and Discussion br STAR Methods

  2022-09-30

  

  Results and Discussion STAR★Methods Author Contributions Conflicts of Interest J.P.F. is a consultant for AstraZeneca, BMS, Johnson and Johnson, Novo Nordisk, and Sanofi, a member of the advisory panel for AstraZeneca and Sanofi, a member of the speaker’s bureau for Sanofi and Novo Nordi

• br Conflict of interest br Transparency document br

  2022-09-30

  

  Conflict of interest Transparency document Acknowledgements We acknowledge our funding sources from the American Heart Association (13EIA4480016) and the National Institute of Health/National Heart, Lung, and Blood Institute (RO1 HL094414). We are very grateful to Dr. Shaohua Xiao and Dr. S

• br Introduction Alzheimer s disease AD affects ca million

  2022-09-30

  

  Introduction Alzheimer's disease (AD) affects ca. 46 million people worldwide [1] and it is expected that the number will double or triple by 2030 or 2050, respectively, while no significant progress has been made in research for early diagnosis and new efficient therapies. Currently available me

• br Materials and methods br Results and discussion br

  2022-09-30

  

  Materials and methods Results and discussion Conclusions Acknowledgements This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684), and also by t

• Mallory stained sections showed significant increase in

  2022-09-30

  

  Mallory stained sections showed significant increase in collagen fiber deposition around the hepatic nodules together with significant increase in positive immune-reaction to α-SMA in TAA-treated group. This was in accordance with previous studies which reported that myofibroblasts which were develo

• Results of studies on fish FBPase are somewhat confusing alt

  2022-09-30

  

  Results of studies on fish FBPase are somewhat confusing: although fishes skeletal muscles possess relatively high FBPase activity (Knox et al., 1980, Lushchak et al., 2001) and the isozyme present therein has kinetic properties typical to all vertebrates muscle FBPases (Rosenmann et al., 1977), inv

• The product chain length determination mechanism of

  2022-09-30

  

  The product chain-length determination mechanism of -prenyltransferases has not yet been elucidated, although mutational analyses of highly conserved residues and of characteristic amino Nitrotetrazolium Blue chloride residues in each subfamily of -prenyltransferases have enabled the understanding

• br Acknowledgements br Insulin is

  2022-09-29

  

  Acknowledgements Insulin is a vital peptide hormone with the exclusive capacity to regulate the blood glucose that entirely is secreting from pancreatic β cells (Kasai et al., 2014). The human insulin comprises 51 amino cytidine synthesis residues, with a molecular mass of 5.808 kDa. INS, resp

• STAR Methods br Acknowledgments We thank C Hong R Huang

  2022-09-29

  

  STAR★Methods Acknowledgments We thank C. Hong, R. Huang, and Z. Yu at the HHMI Janelia cryo-EM facility for help with microscope operation and data collection. We thank A. Müller, W. Kan, and W. Weis for help with the SEC-MALS analysis and M. Elazar and J. Glenn for the use of equipment. P. Love

• br Materials and methods br Results br

  2022-09-29

  

  Materials and methods Results Discussion Directly modulating specific target proteins and signaling pathways with small-molecule drugs or agonistic Telbivudine synthesis is widely used for cancer metastasis therapies [[39], [40], [41]]. ANXA7 acts as a metastasis suppressor in prostate canc

• br Discussion Agonist and antagonist action at

  2022-09-28

  

  Discussion Agonist and antagonist action at the GluN1/GluN3 nonreceptor tyrosine kinase is known to be complex [4], [10]. Recombinant GluN1/GluN3 receptors produce only small excitatory currents in response to glycine, likely because of a combination of activation via GluN3 and desensitization vi

• Active compounds and were further tested and EC and

  2022-09-28

  

  Active compounds , , and were further tested and EC and pEC values were determined as shown in . Compound showed EC of 0.97μM (pEC 6.01) with 84.5% maximal response, which suggests that introduction of alkyl chain on aromatic nucleus of , resulted in improved GPR40 agonistic activity than that of

• The transporter was successfully expressed in MSCs and

  2022-09-28

  

  The transporter was successfully expressed in MSCs and HEK 293 cells. In both cell types, the expression of YFP-EAAT2 was confirmed by immunological staining and flow cytometry. The functionality of the transporter was determined by [3H]glutamate uptake assays, and the blood glutamate-grabbing activ

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