• While HTPCs are not immune cells they

  2025-02-06

  

  While HTPCs are not immune cells, they produce IL-6, MCP-1 and other immunologically relevant factors (Mayer et al., 2016). Our results demonstrated that epinephrine and phenylephrine increased the mRNA expression levels of COX-2, IL-6 and MCP-1 in HTPCs without affecting the mRNA expression level o

• The acetylcholinesterase AChE inhibitor tacrine THA exerts n

  2025-02-06

  

  The acetylcholinesterase (AChE) inhibitor, tacrine (THA), exerts neuroprotective effects in time- and does-dependent manners against glutamate neurotoxicity (Takada-Takatori et al., 2006a, 2006b) and amyloid-β protein toxicity in PC12, a pheochromocytoma line (Wang et al., 2002; Xiao et al., 2000).

• br Dihydrotestosterone in adult fish and frogs br New perspe

  2025-02-06

  

  Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance

• Introduction Cancer which is responsible for a million death

  2025-02-06

  

  Introduction Cancer, which is responsible for a million deaths each year, is universally feared, and approximately 50% of newly diagnosed cases can be cured [1]. The existing cancer treatments, including surgery, chemotherapy, radiotherapy or a combination of them, are quickly losing efficacy. The

• br Introduction Melatonin N acetyl methoxytryptamine

  2025-02-06

  

  Introduction Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone which is mainly secreted from the pineal gland. Melatonin is a highly conserved molecule present not only in vertebrates but also in nonvertebrates such as bacteria, protists, fungi, macroalgae, and plants (Cecon et al., 2017

• The previous reports studied only

  2025-02-06

  

  The previous reports studied only the apoptosis process in a single cell. In our case we generalized these models inspired by the results of Albeck et al. (2008) and Raychaudhuri et al. (2008), to study the apoptosis cell death after photodynamic therapy in those areas of the tumor that are not expo

• br Findings br Discussion br Conclusions Midwives were

  2025-02-05

  

  Findings Discussion Conclusions Midwives were more likely to provide effective antimalaria services (including two doses of IPT during the second and third trimesters of pregnancy) to pregnant women if Conflict of interest Authors’ contributions Funding Acknowledgements Resea

• br Materials and methods br Results br Discussion

  2025-02-05

  

  Materials and methods Results Discussion Prostate cancer is the most common cancer in men in the United States and the second leading cause of cancer death. Therapeutic interventions include mainly: radical prostatectomy or radiation therapy (RT), with or without androgen deprivation therap

• br Introduction Nonalcoholic fatty liver disease NAFLD is

  2025-02-05

  

  Introduction Nonalcoholic fatty liver disease (NAFLD) is a clinicopathologic spectrum of liver pathologies associated with excessive accumulation of fat in the liver. This spectrum is continuous but can be graded based on pathological features; in increasing severity, these are: bland steatosis,

• ap-1 transcription factor DAergic as well as GABAergic and g

  2025-02-05

  

  DAergic, as well as GABAergic and glutamatergic neurons, send projections to target forebrain structures, such as the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC), and support diverse functional roles (Carr and Sesack, 2000a, Carr and Sesack, 2000b, Omelchenko and Sesack, 2009, Taylor

• kn 47 australia br Endocytosis of AdipoR Surface

  2025-02-05

  

  Endocytosis of AdipoR1 Surface receptor activity may be shut down by endocytic uptake and subsequent lysosomal degradation of the proteins [20]. Clathrin-dependent endocytosis (CDE) has been extensively studied and internalization from the plasma membrane is mediated through clathrin-coated pits

• To verify whether circulating APN could protect

  2025-02-05

  

  To verify whether circulating APN could protect cognitive function during aging, we detected the alterations in circulating adipoenctin levels in aging rats. Our results suggested that circulating APN levels reduced with age. Kawasumi et al’s study results are consistent with ours. They concluded th

• The assay performance was estimated using

  2025-02-05

  

  The assay performance was estimated using Z′-factors (plotted in Fig. 2A) according to Zhang et al. calculated for each plate comparing positive (in the absence of an inhibitor) and negative controls (in the presence of an AdK inhibitor). The mean Z′-factor±SD was determined to be 0.7±0.1, indicativ

• m-Chlorophenylbiguanide hydrochloride receptor That disassem

  2025-02-05

  

  That disassembling m-Chlorophenylbiguanide hydrochloride receptor filaments transport chromosomes towards the spindle in oocytes may be surprising at first sight. On the other hand, it is well established that chromosome movement during anaphase is driven by the depolymerization of microtubules [20]

• br Acknowledgements br Introduction Thus

  2025-02-03

  

  Acknowledgements Introduction Thus, damage to the alamarblue assay may produce severe consequences (National Research Council, 1992). Indeed, though the nervous system has several compensatory and adaptive mechanisms, it is vulnerable to toxic insult, due to its inability to regenerate after

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