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br Materials and methods br Results br Discussion Cellular
2018-10-26

Materials and methods Results Discussion Cellular therapeutics may function via either replacement of a lost cell population (e.g. generation of new dopamine neurons or myelinating oligodendrocytes), restoration of a cellular function (e.g. synthesis/secretion of an enzyme in the case of a
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br Material methods br Results br Discussion Several LSC
2018-10-26

Material & methods Results Discussion Several LSC culture systems have been developed to re-create the LSC niche in vitro and to avoid the cross-contamination with non-human feeder purchase CMX001 (Sharma et al., 2012; Xie et al., 2012; Chen et al., 2013; Mei et al., 2014). It has been sug
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The catenindependent Wnt signaling pathway is
2018-10-26

The β-catenindependent Wnt signaling pathway is also important in the modulation of cell proliferation, cell survival, and embryo development [74–76] and is also identified as a regulator of stem cell fate determination [77,78]. It was found that phosphorylation levels of c-Myc and β-catenin (target
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br Experimental Procedures Detailed information on the exper
2018-10-26

Experimental Procedures Detailed information on the experimental procedures can be found in the Supplemental Information File. Author Contributions Introduction Although cell-fate decisions are fairly stable in vivo, somatic these can be reprogrammed back into pluripotency in vitro by ect
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The capacity to delay cell cycle progression at the G
2018-10-26

The capacity to delay cell-cycle progression at the G1/S transition is central to tumor suppression by RB proteins, predominantly via interaction with, and inhibition of, the E2F family of S-phase transcriptional activators. In Drosophila, the role of Rbf proteins in cell-cycle regulation is conside
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Finally there is a diversity
2018-10-26

Finally, there is a ion channel of approaches to latent class analysis, including approaches to the inclusion of covariates. Results can be difficult to compare across studies because they are highly dependent on the measures and methods of analysis (Berrigan et al., 2003; de Vries et al., 2008; Mc
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Thematic synthesis was used to identify important and recurr
2018-10-26

Thematic synthesis was used to identify important and recurrent themes (conducted in 2015) (Thomas & Harden, 2008). This method was developed based on the qualitative analytical technique ‘thematic analysis’ and borrows from traditional systematic review methods. It was developed with the aim that t
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The quality of each paper
2018-10-26

The quality of each paper was depicted by a score summarising the metrics to provide an overall impression of the quality of the available evidence. A weighting system was employed whereby the score for each metric was divided by the maximum possible value so that each metric had the same weighting
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Our results reinforce findings from previous studies support
2018-10-26

Our results reinforce findings from previous studies supporting a link between growth through age 1 year and cognitive achievement in childhood (Crookston et al., 2013). Nevertheless, a limitation of our study is that we do not have anthropometric measures at age 2 years and thus our results are not
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Together these findings demonstrate the benefit
2018-10-26

Together these findings demonstrate the benefit of simultaneous analysis in elucidating potential pathways between the environment and activity, by ensuring that significant relationships are not obscured by unaccounted for aspects of the environment. However, few studies used interaction or mediati
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adenosine receptor antagonist An individual can maintain var
2018-10-26

An individual can maintain various social identities simultaneously, and one will stand out among the rest when the combination of personal and situational characteristics propitiate the ‘depersonalization’ of personal identity. Depersonalization “does not insinuate a negative connotation in the sen
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Surface characteristics and pore structures of adsorbents ar
2018-10-26

Surface characteristics and pore structures of adsorbents are the main properties in determining the performance of adsorption, based on equilibrium and rate properties as factors needed for plant design. A high surface area to volume ratio will determine a successful adsorbent as adsorption is a su
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br Introduction Narcolepsy is a chronic disturbance that lea
2018-10-26

Introduction Narcolepsy is a chronic disturbance that leaves patients incapacitated in most cases; it is characterized by an abnormal sleep pattern that may include excessive daytime sleepiness, sleep architecture alterations, and rapid eye movement (REM) sleep pathological manifestations, includ
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Not only the culture but
2018-10-26

Not only the culture, but also the domicile and gender may influence sleep. Girls have been found to have longer sleep and they spend more time in motionless sleep [16]. To make the issue further complex, a study from Brazil showed that girls had a longer nighttime sleep on holidays but not on weekd
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This study describes the development of an EW
2018-10-26

This study describes the development of an EW fiber-optic sensor for the detection of matrix metalloproteinase 2 (MMP-2) and 9 (MMP-9) activities. In the context of pressure and venous leg ulcers, an elevated and persistent activity of these proteases has been associated with a loss of extracellular
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